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Salinomycin induces massive apoptosis in the multidrug-, radiation- and apoptosis-resistant human cancer cells. Salinomycin-induced apoptosis is independent of tumor suppressor protein p53, caspase activation, the CD95/CD95 ligand system, and the proteasome. Salinomycin fails to induce apoptosis in normal human peripheral CD4+ T lymphocytes.
Free Shipping. Cash On Delivery! Salinomycin is a coccidiostat and carboxylic polyether potassium ionophore with antibiotic and anti-cancer properties.. Cited in 2 publications. My heart goes to all of you affected with cancer.
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It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma. Salinomycin price,Product name : Salinomycin Synonyms : (2R)-2-((5S)-6-{5-[(10S,12R)-2-((6S,5R)-5-Ethyl-5-hydroxy-6-methylperhydro-2H-pyran-2-yl)-15-hydroxy-2,10,12 Salinomycin toxicity in turkeys has been reported on numerous occasions. Do not feed to turkeys. Clinically, the toxicity symptom of salinomycin in birds include feed refusal, muscular weakness, sternal recumbency, diarrhea, weight depression and death. We are offering a range of Salinomycin (Coccidoline-S).
In the current study, Conclusions: Synthetic structural analogs of salinomycin, previously shown to exhibit increased I think I destroyed every art book you could buy in a bookshop.
Salinomycin in grams/ton Combination in grams/ton Indications for use Limitations Sponsor (i) 40 to 60: Broiler, roaster, and replacement (breeder and layer) chickens: For the prevention of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. maxima, E. brunetti, and E. mivati
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2017-03-28 · There are very few drugs available in market which target CSCs. Salinomycin is known for selective killing CSCs and sensitizing tumor cells at a very low concentration. It has exhibited toxicity over a broad range of cancers. Salinomycin sensitized tumor cells for many chemotherapeutic drugs by inhibiting many MDR genes.
Salinomycin has been shown by Piyush Gupta et al. of the Massachusetts Institute of Technology and the Broad Institute to kill breast cancer stem cells in mice at least 100 times more effectively than the anti-cancer drug paclitaxel. Salinomycin is able to effectively eliminate CSCs and to induce partial clinical regression of heavily pretreated and therapy-resistant cancers. It has also been demonstrated as a positive ionotropic and chronotropic agent that increased cardiac output, left ventricular systolic pressure, heart rate, mean arterial pressure, coronary artery vasodilatation and blood flow, and plasma Salinomycin was used as a standard in the development of LC-MS/MS method for detection of residual coccidiostats in egg and muscle samples. It was used to screen out CD44 + CD24-mesenchymal-like subpopulation within breast carcinomas.
Purity: ≥98%, Molecular Formula: C42H70O11, MW: 751.00
Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug. manufacturer | order | distributor | buy 55721-31-8| 55721-31-8 Supplier | purchase
At Alibaba.com, a wide selection of salinomycin is available to cater to all the health needs of your animal, ensuring that you will always have what you need no matter the animal you are buying the salinomycin for. Their active ingredients have been carefully selected to ensure that they address the intended and specified health requirements. Salinomycin sodium salt (Salinomycin sodium), an antibiotic potassium ionophore, is a potent inhibitor of Wnt/β-catenin signaling.
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Name: Salinomycin CAS No. 53003-10-4 Character: white or light yellow crystalline powder have a special smelly Melting point: 140-142°C Style: 10% Salinomycin premix; 12% Salinomycin premix; 24% Salinomycin premix Advantage: 1. Buy salinomycin from ChemDirect.com marketplace. Also knows as procoxacin,coxistac,bio-cox,unii-62uxs86t64,chebi:80025,62uxs86t64,salinomycine [inn-french Vulcanchem offers qualified products for CAS No. 53003-10-4(Salinomycin), please inquire us for more detail. Find 2021 quality & cheap salinomycin for sale.
MDA-MB-436, LLC and 4T1-luc cells were treated for 18 h with 10 μM, 0.5 μM and 0.5 μM doxorubicin or 0.05 μM, 0.5 μM and 0.05 μM salinomycin, respectively. 2019-02-14 · Objectives Salinomycin is a polyether antibiotic with selective activity against human cancer stem cells. The impact of salinomycin on patient-derived primary human colorectal cancer cells has not been investigated so far. Thus, here we aimed to investigate the activity of salinomycin against tumor initiating cells isolated from patients with colorectal cancer.
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Salinomycin in grams/ton Combination in grams/ton Indications for use Limitations Sponsor (i) 40 to 60: Broiler, roaster, and replacement (breeder and layer) chickens: For the prevention of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. maxima, E. brunetti, and E. mivati
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1 Jul 2009 acervulina was reduced in chicks fed diets containing betaine (0.075%) plus salinomycin (66mg/kg) compared to those fed salinomycin only.
It has also been demonstrated as a positive ionotropic and chronotropic agent that increased cardiac output, left ventricular systolic pressure, heart rate, mean arterial pressure, coronary artery vasodilatation and blood flow, and plasma Salinomycin was used as a standard in the development of LC-MS/MS method for detection of residual coccidiostats in egg and muscle samples. It was used to screen out CD44 + CD24-mesenchymal-like subpopulation within breast carcinomas. Packaging 5, 25, 50 mg in glass bottle Biochem/physiol Actions Salinomycin, Ready Made Solution (Antibiotic 61477, Coxxistac); Streptomyces albus, >= 98% HPLC; Salinomycin was used to induce apoptosis in human CD4+ T-cell leukemia cells4 and gastric cancer cells; Chemical structure: polyether; Salinomycin, a monocarboxylic polyether antibioti salinomycin-sodium-premix, Find Quality salinomycin-sodium-premix and Buy salinomycin-sodium-premix from Reliable Global salinomycin-sodium-premix Suppliers from mobile site on m.alibaba.com References General References.
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